Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with Heat-Killed Brucella abortus Short Title Hepcidin, Interleukin-6 and Anemia of Inflammation
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Short Title Hepcidin, Interleukin-6 and Anemia of Inflammation Authors (Full Names) Sara Gardenghi, Tom M Renaud, Alessandra Meloni, Carla Casu, Bart J Crielaard, Laura M Bystrom, Noa Greenberg-Kushnir , Barbra J Sasu, Keegan S Cooke, and Stefano Rivella Affiliations/Institutions Department of Pediatric Hematology-Oncology, Children’s and Cancer Blood Foundation Laboratories, Weill Cornell Medical College, New York, NY. Department of Pediatric Hematology-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY. Oncology Discovery Research, Amgen Inc, Thousand Oaks, CA. Corresponding Author: Name: Sara Gardenghi Address: 515 East, 71 Street, Room S703 E-mail: [email protected] Phone: 212-746-4938 Fax: 212-746-8423
منابع مشابه
Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus.
Anemia of inflammation (AI) is commonly observed in chronic inflammatory states and may hinder patient recovery and survival. Induction of hepcidin, mediated by interleukin 6, leads to iron-restricted erythropoiesis and anemia. Several translational studies have been directed at neutralizing hepcidin overexpression as a therapeutic strategy against AI. However, additional hepcidin-independent m...
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Erythroferrone (ERFE) is an erythropoiesis-driven regulator of iron homeostasis. ERFE mediates the suppression of the iron-regulatory hormone hepcidin to increase iron absorption and mobilization of iron from stores. We examined the role of ERFE in the recovery from anemia of inflammation (AI) induced by injection of heat-killed Brucella abortus. B abortus-treated wild-type mice developed a mod...
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Anemia is a common complication of infections and inflammatory diseases, but the few mouse models of this condition are not well characterized. We analyzed in detail the pathogenesis of anemia induced by an injection of heat-killed Brucella abortus and examined the contribution of hepcidin by comparing wild-type (WT) to iron-depleted hepcidin-1 knockout (Hamp-KO) mice. B abortus-treated WT mice...
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Hepcidin controls systemic iron availability, and its excess contributes to the anemia of chronic diseases, the most prevalent anemia in hospitalized patients. We previously reported that heparins are efficient hepcidin inhibitors both in vitro and in vivo, but their anticoagulant activity limits therapeutic use. We studied nonanticoagulant heparins produced by N-acetylation and oxidation/reduc...
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Anemia of cancer (AC) may contribute to cancer-related fatigue and impair quality of life. Improved understanding of the pathogenesis of AC could facilitate better treatment, but animal models to study AC are lacking. We characterized four syngeneic C57BL/6 mouse cancers that cause AC. Mice with two different rapidly-growing metastatic lung cancers developed the characteristic findings of anemi...
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تاریخ انتشار 2013